She may just be talking to you. Or she may be lonely. Probably both. And, since you get up and pay attention to her when she meows, she's learning it's a good way to train you. Could you get another cat? If you found a mama whose kittens had been adopted and who needed her own furever home, that could be a good match.
It might also help if you played with her really vigorously right before bed time. Many of us have Da Bird, which is basically feathers on a string attached to a wand. My babies go crazy for it and will chase it until they are too tired to do anymore. Make sure you don't leave it out where she can get it when you aren't watching. Some (many) cats eat string, yarn, ribbon, etc. and it's not good for them.
If she doesn't like the feather toys, try rolling a ball for her to chase. My Cheetah will play fetch, but the others insist that I go get the ball and throw it again. Then you'll be the one who ends up tired, but that's not all bad, you will sleep through the meowing.
